Primary Publications

55. Eur J Org 2023, 27, e202301212. C J Niland, J J Ruddy, M P O’Fearraigh, E M McGarrigle*— Asymmetric Organocatalyzed Synthesis of α-Aminophosphinates via Thiourea Anion-Binding Catalysis. DOI: 10.1002/ejoc.202301212

54. Chem Commun 2023, 59, 13711-13714. M B Reddy, E M McGarrigle*— Visible-light-induced bifunctionalisation of (homo)propargylic amines with CO2 and arylsulfinates. DOI:10.1039/D3CC04160C

53. Chem Commun 2023, 59, 7767-7770. M B Reddy, E M McGarrigle*— Iodine-mediated photoinduced tuneable disulfonylation and sulfinylsulfonylation with sodium arylsulfinates. DOI: 10.1039/D2CC02011H

52. Org Biomol Chem 2023, 21, 1027-1032. P E McDermott, M P Ó Fearraigh, A M Horan, E M McGarrigle*— Thiourea-catalysed conjugate additions of amines to vinyl phosphonates and phosphinates. DOI: 10.1039/D2OB02116A

51. Chem Commun 2023, 59, 330-333. L Hallen, A Horan, B Twamley, E M McGarrigle,* S M Draper*— Accessing unsymmetrical Ru(II) bipyridine complexes: a versatile synthetic mechanism for fine tuning photophysical properties. DOI: https://doi.org/10.1039/D2CC04910D

50. Org Lett 2021, 23, 9089-9093. A M Horan, V K Duong,* E M McGarrigle*— Synthesis of Bis-heteroaryls Using Grignard Reagents and Pyridylsulfonium Salts. DOI:10.1021/acs.orglett.1c03379

49. Chem Sci 2021, 12, 10070-10075. I Pongener, D A Pepe, J J Ruddy, E M McGarrigle*— Stereoselective β-mannosylations and β-rhamnosylations from glycosyl hemiacetals mediated by lithium iodide. DOI: 10.1039/D1SC01300A

48. J Org Chem 2021, 86, 3907-3922. A Seitz, R C Wende, E Roesner, D Niedek, C Topp, A C Colgan, E M McGarrigle, and P R Schreiner* — Site-Selective Acylation of Pyranosides with Oligopeptide Catalysts. DOI: 10.1021/acs.joc.0c02772

47. Org Lett 2020, 22, 8451-8457. V K Duong, A M Horan, E M McGarrigle* — Synthesis of Pyridylsulfonium Salts and Their Application in the Formation of Functionalized Bipyridines. DOI: 10.1021/acs.orglett.0c03048

46. J Biol Chem 2020, 295, 6482-6497. R Ward, J J Kaylor, D F Cobice, D A Pepe, E M McGarrigle, S E Brockerhoff, J B Hurley, G H Travis, B N Kennedy* — Non-photopic and photopic visual cycles differentially regulate immediate, early, and late phases of cone photoreceptor-mediated vision. DOI: 10.1074/jbc.RA119.011374

45. Org Biomol Chem 2019, 17, 7531-7535. I Pongener, K Nikitin  and  E M McGarrigle* — Synthesis of Glycosyl Chlorides using Catalytic Appel Conditions. DOI: 10.1039/C9OB01544B 

44. Chem Sci 2019, 10, 508-514. G A Bradshaw, A C Colgan, N P Allen, I Pongener, M B Boland, Y Ortin and E M McGarrigle* — Stereoselective organocatalyzed glycosylations – thiouracil, thioureas and monothiophthalimide act as Brønsted acid catalysts at low loadings. DOI: 10.1039/C8SC02788A

43. Synthesis 2018, 50, 3337-3343. M P O’Fearraigh, J V Matlock, E M McGarrigle*, V K Aggarwal* — Synthesis of Isothiocineole and Application in Multigram-Scale Sulfur Ylide Mediated Asymmetric Epoxidation and Aziridination.[pdf] DOI: 10.1055/s-0037-1609580

42. J Org Chem 2016, 81, 11394-11396. A C Colgan, H Müller-Bunz, E M McGarrigle* — Benzylation Reactions in DMF Lead to an Impurity Which Acts as an Organocatalyst Poison in Thiourea-Catalyzed Glycosylations. DOI: 10.1021/acs.joc.6b01914

41. Org Lett 2016, 18, 4222-4225. S Medina, M J Harper, E I Balmond, S Miranda, G E M Crisenza, D M Coe, E M McGarrigle, M C Galan* — Stereoselective Glycosylation of 2-Nitrogalactals Catalyzed by a Bifunctional Organocatalyst. DOI: 10.1021/acs.orglett.6b01962

40. Org Lett 2015, 17, 5044–5047. J V Matlock, T D Svejstrup, P Songara, S Overington, E M McGarrigle,* V K Aggarwal* — Synthesis of 6- and 7-Membered N-Heterocycles Using α-Phenylvinylsulfonium Salts. DOI: 10.1021/acs.orglett.5b02516 [1 of the top 10 most read articles published in Org Lett in Oct 2015. Highlighted in Synfacts 2015, 11, 1249 V Snieckus, M E Dalziel, and featured in the chemistry views website, 6th October 2015]

39. J Org Chem 2014, 79, 10226-10239. J V Matlock, S P Fritz, S A Harrison, D M Coe, E M McGarrigle,* V K Aggarwal* — Synthesis of α-Substituted Vinylsulfonium Salts and Their Application as Annulation Reagents in the Formation of Epoxide- and Cyclopropane-Fused Heterocycles. DOI: 10.1021/jo501885z

38. Angew Chem Int Ed 2014, 53, 8190-8194. E I Balmond, D Benito-Alifonso, D M Coe, R W Alder, E M McGarrigle*, M C Galan* — A 3,4-trans-Fused Cyclic Protecting Group Facilitates α-Selective Catalytic Synthesis of 2-Deoxyglycosides. DOI: 10.1002/anie.201403543

37. J Am Chem Soc 2013, 135, 11951–11966. I Illa, M Namutebi, C Saha, M Ostovar, C C Chen, M F Haddow, S Nocquet-Thibault, M Lusi, E M McGarrigle,* V K Aggarwal* — Practical and Highly Selective Sulfur Ylide-Mediated Asymmetric Epoxidations and Aziridinations Using a Cheap and Readily Available Chiral Sulfide: Extensive Studies To Map Out Scope, Limitations, and Rationalization of Diastereo- and Enantioselectivities. DOI: 10.1021/ja405073w

36. Chem Eur J 2013, 19, 10827-10831. S P Fritz, J V Matlock, E M McGarrigle,* V K Aggarwal* — Efficient Synthesis of Cyclopropane-Fused Heterocycles with Bromoethylsulfonium Salt. DOI: 10.1002/chem.201302081

35. Helv Chim Acta 2012, 95, 2384–2398. S P Fritz, Z Ali, M G Unthank, E M McGarrigle, V K Aggarwal* — (2-Bromoethyl)sulfonium Trifluoromethanesulfonates in Stereoselective Annulation Reactions for the Formation of Fused Bicyclic Epoxides and Aziridines. DOI: 10.1002/hlca.201200455

34. Org Lett 2012, 14, 6370–6373. S P Fritz, T H West, E M McGarrigle*, V K Aggarwal* — Diastereoselective Synthesis of CF3-Substituted, Epoxide-Fused, Heterocycles with β-(Trifluoromethyl)vinylsulfonium Salts. DOI: 10.1021/ol303200n

33 Angew Chem Int Ed 2012, 51, 9152–9155. E I Balmond, D M Coe, M C Galan,* E M McGarrigle* — α-Selective Organocatalytic Synthesis of 2-Deoxygalactosides. DOI: 10.1002/anie.201204505

32. Synthesis 2012, 44, 1584–1590. S P Fritz, J F Moya, M G Unthank, E M McGarrigle*, V K Aggarwal* — ‘An Efficient Synthesis of Azetidines with (2-Bromoethyl)sulfonium Triflate.’ DOI: 10.1055/s-0031-1290951

31. Eur J Org Chem 2012,160–166. M Yar, S P Fritz, P J Gates, E M McGarrigle, V K Aggarwal* — ‘Synthesis of N-Vinyloxazolidinones and Morpholines from Aminoalcohols and Vinylsulfonium Salts: Analysis of the Outcome’s Dependence on N-Protecting Group by Nanospray Mass Spectrometry.’ DOI: 10.1002/ejoc.201101272

30. Org Lett 2011, 13, 3060–3063. E M McGarrigle,* S P Fritz, L Favereau, M Yar, V K Aggarwal* — An Efficient Synthesis of Imidazolinium salts using Vinyl Sulfonium Salts. DOI: 10.1021/ol2009472

29. Chem Asian J 2011, 6, 372–375. M Yar, M G Unthank, E M McGarrigle,* V K Aggarwal* — ‘Remote Chiral Induction in the vinyl sulfonium salt-mediated synthesis of chiral epoxide-fused heterocycles.’ DOI: 10.1002/asia.201000817

28. Eur J Org Chem 2011, 3156–3164. S P Fritz, A Mumtaz, M Yar, E M McGarrigle, V K Aggarwal* — ‘Sulfinamides as highly effective amine protecting groups and their use in the conversion of aminoalcohols into morpholines.’ DOI: 10.1002/ejoc.201100337

27. J Am Chem Soc 2010, 132, 1828–1830. O Illa, M Arshad, A Ros, E M McGarrigle, V K Aggarwal* — ‘Practical and highly selective sulfur ylide mediated asymmetric epoxidations and aziridinations using an inexpensive, readily available chiral sulfide. Applications to the synthesis of quinine and quinidine.’ DOI: 10.1021/ja9100276 [The sulfide described is now available in either enantiomeric form from TCI, Cat no: T2578 and T2579; Aldrich 766429. The paper was highlighted by ACS Noteworthy Chemistry (March 15, 2010) and the ‘TotallySynthetic.com/blog/’]

26. J Am Chem Soc 2010, 132, 7626–7630. S L Riches, C Saha, N Fontán Filgueira, E Grange, E M McGarrigle, V K Aggarwal* — ‘On the mechanism of ylide cyclopropanations: evidence for participation of intramolecular proton transfer pathways.’ DOI: 10.1021/ja910631u

25. Tetrahedron: Asymmetry 2010, 21, 1771–1776. M Arshad, M A Fernández, E M McGarrigle, V K Aggarwal* — Synthesis of quinine and quinidine using sulfur ylide mediated asymmetric epoxidation as a key step. DOI: 10.1016/j.tetasy.2010.04.046

24. Phosphorus, Sulfur Silicon Relat Elem 2010, 185, 1250–1272. M Hassan-Namutebi, E M McGarrigle,* V K Aggarwal* — ‘Ring-opening of NH-Aziridines with Thiols in Ionic Liquids – application to the synthesis of Aminosulfide Catalysts for Asymmetric Epoxidation of Aldehydes.’ DOI: 10.1080/10426501003773787

23. Org Lett 2009, 11, 257–260. M Yar, E M McGarrigle,* V K Aggarwal* — ‘Bromoethylsulfonium Salt: A More Effective Annulation Reagent for the Synthesis of 6- and 7-Membered 1,4-Heterocyclic Compounds.’ DOI: 10.1021/ol8023727 [The Reagent described is now available from Aldrich, Cat no: 706345]

22. Tetrahedron Lett 2009, 50, 3482–3484. V K Aggarwal,* N Barberos, E M McGarrigle, G Mickle, R Navas, J R Suárez, M G Unthank, M Yar — ‘The fate of the tert-butylsulfinyl auxiliary after acid-promoted cleavage – a method for recycling t-BuSONH2.’ DOI: 10.1016/j.tetlet.2009.03.020

21. Synlett 2008, 2191–2195. C G Kokotos, E M McGarrigle, V K Aggarwal* — ‘Sulfur Ylide Mediated Three-Component Aziridination and Epoxidation Reactions using Vinyl Sulfonium Salts.’ DOI: 10.1055/s-2008-1078252 [This article was highlighted in Synfacts 2008, 11, 1142; V Snieckus, J Board. DOI: 10.1055/s-0028-1083487]

20. Chem Asian J 2008, 8–9, 1657–1663. M Hansch, O Illa, E M McGarrigle, V K Aggarwal* — ‘Synthesis and Application of Easily Recyclable Thiomorpholines for Use in Sulfur Ylide Mediated Asymmetric Epoxidation of Aldehydes.’ DOI: 10.1002/asia.200800174

19. Angew Chem Int Ed 2008, 47, 3784–3786. M Yar, E M McGarrigle, V K Aggarwal* — ‘An Annulation Reaction for the Synthesis of Morpholines, Thiomorpholines and Piperazines from β-Heteroatom Amino Compounds and Vinyl Sulfonium Salts.’ DOI: 10.1002/anie.200800373 [The method described has been used in patents by UCB Celltech WO2009/153554, Kudos Pharmaceuticals WO2010/136778, Genentech WO2010/014939]

18. J Am Chem Soc 2007, 129, 9566–9567. E Bergin, C T O’Connor, S B Robinson, E M McGarrigle, C P O’Mahony, D G Gilheany* — ‘Synthesis of P-Stereogenic Phosphorus Compounds. Asymmetric Oxidation of Phosphines under Appel Conditions.’ DOI: 10.1021/ja072925l [Winner of the 2008 Wesley Cocker award from the SCI for the best paper published in Ireland in 2007 of interest to the chemical industry]

17. ARKIVOC 2007, (v), 139–151. V A Moorthie, E M McGarrigle, R Stenson, V K Aggarwal* — ‘Studies towards a Biomimetic Synthesis of α-Cyclopiazonic acid: Synthesis of 5-substituted Isoxazole-4-Carboxylic Esters.’ http://www.arkat-usa.org

16. ARKIVOC 2005, (i), 30–38. E F Clarke, E M McGarrigle, D G Gilheany* — ‘Cr-Salen Mediated Asymmetric Epoxidation of Alkenes: Rational Complex Design and Substrate Scope of Catalyst.’ http://www.arkat-usa.org

15. J Mol Catal A 2005, 231, 205–220. M F Renehan, H-J Schanz, E M McGarrigle, C T Dalton, A M Daly, D G Gilheany* — ‘Unsymmetrical Chiral Salen Schiff Base Ligands: Synthesis and Use in Metal-based Asymmetric Epoxidation Reactions.’ DOI:10.1016/j.molcata.2004.12.034

14. Tetrahedron: Asymmetry 2004, 15, 1343–1354. E M McGarrigle, D Murphy, D G Gilheany* — ‘Ligand tuning in the Chromium–Salen-mediated asymmetric epoxidation.’ DOI:10.1016/j.tetasy.2004.03.010

13. Org Lett 2001, 3, 3435–3438. C P O’Mahony, E M McGarrigle, M F Renehan, K M Ryan, N J Kerrigan, C Bousquet, D G Gilheany* — ‘Asymmetric Alkene Epoxidation with Chromium Oxo Salen Complexes. A Systematic Study of Salen Ligand Substituents.’ DOI: 10.1021/ol010144y