All Publications

Primary Publications

41. J Org Chem 2016, 81, 11394-11396. A C Colgan, H Müller-Bunz, E M McGarrigle* — Benzylation Reactions in DMF Lead to an Impurity Which Acts as an Organocatalyst Poison in Thiourea-Catalyzed Glycosylations. DOI: 10.1021/acs.joc.6b01914

40. Org Lett 2016, 18, 4222-4225. S Medina, M J Harper, E I Balmond, S Miranda, G E M Crisenza, D M Coe, E M McGarrigle, M C Galan* — Stereoselective Glycosylation of 2-Nitrogalactals Catalyzed by a Bifunctional Organocatalyst. DOI: 10.1021/acs.orglett.6b01962

39. Org Lett 2015, 17, 5044–5047. J V Matlock, T D Svejstrup, P Songara, S Overington, E M McGarrigle,* V K Aggarwal* — Synthesis of 6- and 7-Membered N-Heterocycles Using α-Phenylvinylsulfonium Salts. DOI: 10.1021/acs.orglett.5b02516 [1 of the top 10 most read articles published in Org Lett in Oct 2015. Highlighted in Synfacts 2015, 11, 1249 V Snieckus, M E Dalziel, and featured in the chemistry views website, 6th October 2015]

38. J Org Chem 2014, 79, 10226-10239. J V Matlock, S P Fritz, S A Harrison, D M Coe, E M McGarrigle,* V K Aggarwal* — Synthesis of α-Substituted Vinylsulfonium Salts and Their Application as Annulation Reagents in the Formation of Epoxide- and Cyclopropane-Fused Heterocycles. DOI: 10.1021/jo501885z

37. Angew Chem Int Ed 2014, 53, 8190-8194. E I Balmond, D Benito-Alifonso, D M Coe, R W Alder, E M McGarrigle*, M C Galan* — A 3,4-trans-Fused Cyclic Protecting Group Facilitates α-Selective Catalytic Synthesis of 2-Deoxyglycosides. DOI: 10.1002/anie.201403543

36. J Am Chem Soc 2013, 135, 11951–11966. I Illa, M Namutebi, C Saha, M Ostovar, C C Chen, M F Haddow, S Nocquet-Thibault, M Lusi, E M McGarrigle,* V K Aggarwal* — Practical and Highly Selective Sulfur Ylide-Mediated Asymmetric Epoxidations and Aziridinations Using a Cheap and Readily Available Chiral Sulfide: Extensive Studies To Map Out Scope, Limitations, and Rationalization of Diastereo- and Enantioselectivities. DOI: 10.1021/ja405073w

35. Chem Eur J 2013, 19, 10827-10831. S P Fritz, J V Matlock, E M McGarrigle,* V K Aggarwal* — Efficient Synthesis of Cyclopropane-Fused Heterocycles with Bromoethylsulfonium Salt. DOI: 10.1002/chem.201302081

34. Helv Chim Acta 2012, 95, 2384–2398. S P Fritz, Z Ali, M G Unthank, E M McGarrigle, V K Aggarwal* — (2-Bromoethyl)sulfonium Trifluoromethanesulfonates in Stereoselective Annulation Reactions for the Formation of Fused Bicyclic Epoxides and Aziridines. DOI: 10.1002/hlca.201200455

33. Org Lett 2012, 14, 6370–6373. S P Fritz, T H West, E M McGarrigle*, V K Aggarwal* — Diastereoselective Synthesis of CF3-Substituted, Epoxide-Fused, Heterocycles with β-(Trifluoromethyl)vinylsulfonium Salts. DOI: 10.1021/ol303200n

32. Angew Chem Int Ed 2012, 51, 9152–9155. E I Balmond, D M Coe, M C Galan,* E M McGarrigle*α-Selective Organocatalytic Synthesis of 2-Deoxygalactosides. DOI: 10.1002/anie.201204505

31. Synthesis 2012,  44, 1584–1590. S P Fritz, J F Moya, M G. Unthank, E M. McGarrigle*, V K. Aggarwal* — ‘An Efficient Synthesis of Azetidines with (2-Bromoethyl)sulfonium Triflate.’ DOI: 10.1055/s-0031-1290951

30. Eur J Org Chem 2012,160–166. M Yar, S P Fritz, P J Gates, E M McGarrigle, V K Aggarwal* — ‘Synthesis of N-Vinyloxazolidinones and Morpholines from Aminoalcohols and Vinylsulfonium Salts: Analysis of the Outcome’s Dependence on N-Protecting Group by Nanospray Mass Spectrometry.’ DOI: 10.1002/ejoc.201101272

29. Org Lett 2011, 13, 3060–3063. E M McGarrigle,* S P Fritz, L Favereau, M Yar, V K Aggarwal* — An Efficient Synthesis of Imidazolinium salts using Vinyl Sulfonium Salts. DOI: 10.1021/ol2009472

28. Chem Asian J 2011, 6, 372–375. M Yar, M G Unthank, E M McGarrigle,* V K Aggarwal* — ‘Remote Chiral Induction in the vinyl sulfonium salt-mediated synthesis of chiral epoxide-fused heterocycles.’ DOI: 10.1002/asia.201000817

27. Eur J Org Chem 2011, 3156–3164. S P Fritz, A Mumtaz, M Yar, E M McGarrigle, V K Aggarwal* — ‘Sulfinamides as highly effective amine protecting groups and their use in the conversion of aminoalcohols into morpholines.’ DOI: 10.1002/ejoc.201100337

26. J Am Chem Soc 2010, 132, 1828–1830.O Illa, M Arshad, A Ros, E M McGarrigle, V K Aggarwal* — ‘Practical and highly selective sulfur ylide mediated asymmetric epoxidations and aziridinations using an inexpensive, readily available chiral sulfide. Applications to the synthesis of quinine and quinidine.’ DOI: 10.1021/ja9100276 [The sulfide described is now available in either enantiomeric form from TCI, Cat no: T2578 and T2579; Aldrich 766429. The paper was highlighted by ACS Noteworthy Chemistry (March 15, 2010) and the ‘TotallySynthetic.com/blog/]

25. J Am Chem Soc 2010, 132, 7626–7630. S L Riches, C Saha, N Fontán Filgueira, E Grange, E M McGarrigle, V K Aggarwal* — ‘On the mechanism of ylide cyclopropanations: evidence for participation of intramolecular proton transfer pathways.’ DOI: 10.1021/ja910631u

24. Tetrahedron: Asymmetry 2010, 21, 1771–1776. M Arshad, M A Fernández, E M McGarrigle, V K Aggarwal* — Synthesis of quinine and quinidine using sulfur ylide mediated asymmetric epoxidation as a key step. DOI: 10.1016/j.tetasy.2010.04.046

23. Phosphorus, Sulfur Silicon Relat Elem 2010, 185, 1250–1272. M Hassan-Namutebi, E M McGarrigle,* V K Aggarwal* — ‘Ring-opening of NH-Aziridines with Thiols in Ionic Liquids – application to the synthesis of Aminosulfide Catalysts for Asymmetric Epoxidation of Aldehydes.’ DOI: 10.1080/10426501003773787

22. Org Lett 2009, 11, 257–260. M Yar, E M McGarrigle,* V K Aggarwal* — ‘Bromoethylsulfonium Salt: A More Effective Annulation Reagent for the Synthesis of 6- and 7-Membered 1,4-Heterocyclic Compounds.’ DOI: 10.1021/ol8023727 [The Reagent described is now available from Aldrich, Cat no: 706345]

21. Tetrahedron Lett 2009, 50, 3482–3484. V K Aggarwal,* N Barberos, E M McGarrigle, G Mickle, R Navas, J R Suárez, M G Unthank, M Yar — ‘The fate of the tert-butylsulfinyl auxiliary after acid-promoted cleavage – a method for recycling t-BuSONH2.’ DOI: 10.1016/j.tetlet.2009.03.020

20. Synlett 2008, 2191–2195. C G Kokotos, E M McGarrigle, V K Aggarwal* — ‘Sulfur Ylide Mediated Three-Component Aziridination and Epoxidation Reactions using Vinyl Sulfonium Salts.’ DOI: 10.1055/s-2008-1078252 [This article was highlighted in Synfacts 2008, 11, 1142; V Snieckus, J Board. DOI: 10.1055/s-0028-1083487]

19. Chem Asian J 2008, 8–9, 1657–1663. M Hansch, O Illa, E M McGarrigle, V K Aggarwal* — ‘Synthesis and Application of Easily Recyclable Thiomorpholines for Use in Sulfur Ylide Mediated Asymmetric Epoxidation of Aldehydes.’ DOI: 10.1002/asia.200800174

18. Angew Chem Int Ed 2008, 47, 3784–3786. M Yar, E M McGarrigle, V K Aggarwal* — ‘An Annulation Reaction for the Synthesis of Morpholines, Thiomorpholines and Piperazines from β-Heteroatom Amino Compounds and Vinyl Sulfonium Salts.’ DOI: 10.1002/anie.200800373 [The method described has been used in patents by UCB Celltech WO2009/153554, Kudos Pharmaceuticals WO2010/136778, Genentech WO2010/014939]

17. J Am Chem Soc 2007, 129, 9566–9567. E Bergin, C T O’Connor, S B Robinson, E M McGarrigle, C P O’Mahony, D G Gilheany* — ‘Synthesis of P-Stereogenic Phosphorus Compounds. Asymmetric Oxidation of Phosphines under Appel Conditions.’ DOI: 10.1021/ja072925l [Winner of the 2008 Wesley Cocker award from the SCI for the best paper published in Ireland in 2007 of interest to the chemical industry]

16. ARKIVOC 2007, (v), 139–151. V A Moorthie, E M McGarrigle, R Stenson, V K Aggarwal* — ‘Studies towards a Biomimetic Synthesis of α-Cyclopiazonic acid: Synthesis of 5-substituted Isoxazole-4-Carboxylic Esters.’ http://www.arkat-usa.org

15. ARKIVOC 2005, (i), 30–38. E F Clarke, E M McGarrigle, D G Gilheany* — ‘Cr-Salen Mediated Asymmetric Epoxidation of Alkenes: Rational Complex Design and Substrate Scope of Catalyst.’ http://www.arkat-usa.org

14. J Mol Catal A 2005, 231, 205–220. M F Renehan, H-J Schanz, E M McGarrigle, C T Dalton, A M Daly, D G Gilheany* — ‘Unsymmetrical Chiral Salen Schiff Base Ligands: Synthesis and Use in Metal-based Asymmetric Epoxidation Reactions.’ DOI:10.1016/j.molcata.2004.12.034

13. Tetrahedron: Asymmetry 2004, 15, 1343–1354. E M McGarrigle, D Murphy, D G Gilheany* — ‘Ligand tuning in the Chromium–Salen-mediated asymmetric epoxidation.’ DOI:10.1016/j.tetasy.2004.03.010

12. Org Lett 2001, 3, 3435–3438. C P O’Mahony, E M McGarrigle, M F Renehan, K M Ryan, N J Kerrigan, C Bousquet, D G Gilheany* — ‘Asymmetric Alkene Epoxidation with Chromium Oxo Salen Complexes. A Systematic Study of Salen Ligand Substituents.’ DOI: 10.1021/ol010144y

Patents

11. PCT Int Appl 2005. WO 2005118603. D Gilheany, S B Robinson, C P O’Mahony, C T O’Connor, E Bergin, D M Walsh, A Rimkus, E F Clarke, B G Kelly, E M McGarrigle — ‘Chiral Phosphorus Compounds.’ [Commercialised by Celtic Catalysts]

Review Articles (peer-reviewed)

10. Synlett 2013, 24, 2335–2339. E I Balmond, M C Galan,* E M McGarrigle* — ‘Recent Developments in the Application of Organocatalysis to Glycosylations’. DOI: 10.1055/s-0033-1338970 [Invited contribution to special issue for 5th EuCheMS Organic Division Young Investigators Workshop]

9. Chem Rev 2007, 107, 5841–5883. E M McGarrigle, E L Myers, O Illa, M A Shaw, S L Riches, V K Aggarwal* — ‘Chalcogenides as Organocatalysts.’ DOI: 10.1021/cr068402y [Invited contribution to special issue on Organocatalysis] [This article is “highly cited” – in the top 1% of articles published in 2007 by citation count. Source: ISI Web of Science (Thomson Reuters)]

8. Chem Rev 2005, 105, 1563–1602. E M McGarrigle, D G Gilheany* — ‘Chromium- and Manganese-Salen Promoted Epoxidation of Alkenes.’ DOI: 10.1021/cr0306945 [This article is “highly cited” – in the top 1% of articles published in 2005 by citation count. Source: ISI Web of Science (Thomson Reuters)]

Chapters in Edited Books

7. Encyclopedia of Reagents for Organic Synthesis, online; Ed. L A Paquette, D Crich, P L Fuchs, G A Molander; John Wiley & Sons Ltd.; J V Matlock, Varinder K Aggarwal, E M McGarrigle — ‘(2-Bromoethyl)diphenylsulfonium Trifluoromethanesulfonate’; eEROS (2016). DOI: 10.1002/047084289X.rn01921/abstract

6. Encyclopedia of Reagents for Organic Synthesis, online; Ed. L A Paquette, D Crich, P L Fuchs, G A Molander; John Wiley & Sons Ltd.; E I Balmond, M C Galan, E M McGarrigle — ‘N,N′-Bis[3,5-bis(trifluoromethyl)phenyl]thiourea’; eEROS (2014). DOI: 10.1002/047084289X.rn01642

5. Encyclopedia of Reagents for Organic Synthesis, online; Ed. L A Paquette, D Crich, P L Fuchs, G A Molander; John Wiley & Sons Ltd.; O Illa, E M McGarrigle, V K Aggarwal — ‘Bicyclo[2.2.1]heptan-2-one, 7,7-dimethyl-1-(1S,3S,4R)-2- thiabicyclo[2.2.1]hept-3-yl-, (1S,4R)’; eEROS (2012). DOI: 10.1002/047084289X.rn01477

4. Encyclopedia of Reagents for Organic Synthesis, online; Ed. L A Paquette, D Crich, P L Fuchs, G A Molander; John Wiley & Sons Ltd.; M Yar, E M McGarrigle, V K Aggarwal — ‘Sulfonium, Ethenyldiphenyl-, 1,1,1-Trifluoromethanesulfonate’, eEROS (2012). DOI: 10.1002/047084289X.rn01409

3. Stereoselective Synthesis 2: Stereoselective Reactions of Carbonyl and Imino Groups, Chapter 2.6, p311–347 (Ed. G A Molander); Science of Synthesis, Georg-Thieme-Verlag KG, Stuttgart, 2011. V K Aggarwal, E M McGarrigle, M A Shaw — Epoxidation and Aziridination of Carbonyl Groups and Imines.

2. Enantioselective Organocatalysis: Reactions and Experimental Procedures, Ed. P I Dalko; Wiley–VCH, Weinheim; 2007, Chapter 10, p357–389; E M McGarrigle, V K Aggarwal — ‘Ylide-Based Reactions.’

1. Encyclopedia of Reagents for Organic Synthesis, 2nd Ed. Vol. 13, 2009; Ed. L A Paquette, D Crich, P L Fuchs, G A Molander, John Wiley & Sons Ltd.; E M McGarrigle, V K Aggarwal — ‘Trimethylsulfoxonium Iodide’, first update; eEROS (2007). DOI: 10.1002/9780470842898.rt351.pub2