Selected Publications

Angew Chem Int Ed 2014, 53, 8190-8194. E I Balmond, D Benito-Alifonso, D M Coe, R W Alder, E M McGarrigle*, M C Galan* — A 3,4-trans-Fused Cyclic Protecting Group Facilitates α-Selective Catalytic Synthesis of 2-Deoxyglycosides. DOI: 10.1002/anie.201403543

J Am Chem Soc 2013, 135, 11951–11966. I Illa, M Namutebi, C Saha, M Ostovar, C C Chen, M F Haddow, S Nocquet-Thibault, M Lusi, E M McGarrigle,* V K Aggarwal* — Practical and Highly Selective Sulfur Ylide-Mediated Asymmetric Epoxidations and Aziridinations Using a Cheap and Readily Available Chiral Sulfide: Extensive Studies To Map Out Scope, Limitations, and Rationalization of Diastereo- and Enantioselectivities. DOI: 10.1021/ja405073w

Angew Chem Int Ed 2012, 51, 9152–9155. E I Balmond, D M Coe, M C Galan,* E M McGarrigle* — α-Selective Organocatalytic Synthesis of 2-Deoxygalactosides. DOI: 10.1002/anie.201204505

Org Lett 2011, 13, 3060–3063. E M McGarrigle,* S P Fritz, L Favereau, M Yar, V K Aggarwal* — An Efficient Synthesis of Imidazolinium salts using Vinyl Sulfonium Salts. DOI: 10.1021/ol2009472

J Am Chem Soc 2010, 132, 1828–1830.O Illa, M Arshad, A Ros, E M McGarrigle, V K Aggarwal* — ‘Practical and highly selective sulfur ylide mediated asymmetric epoxidations and aziridinations using an inexpensive, readily available chiral sulfide. Applications to the synthesis of quinine and quinidine.’ DOI: 10.1021/ja9100276 [The sulfide described is now available in either enantiomeric form from TCI, Cat no: T2578 and T2579. The paper was highlighted by ACS Noteworthy Chemistry (March 15, 2010) and the ‘TotallySynthetic.com/blog/]

J Am Chem Soc 2010, 132, 7626–7630. S L Riches, C Saha, N Fontán Filgueira, E Grange, E M McGarrigle, V K Aggarwal* — ‘On the mechanism of ylide cyclopropanations: evidence for participation of intramolecular proton transfer pathways.’ DOI: 10.1021/ja910631u

Angew Chem Int Ed 2008, 47, 3784–3786. M Yar, E M McGarrigle, V K Aggarwal* — ‘An Annulation Reaction for the Synthesis of Morpholines, Thiomorpholines and Piperazines from β-Heteroatom Amino Compounds and Vinyl Sulfonium Salts.’ DOI: 10.1002/anie.200800373 [The method described has been used in patents by UCB Celltech WO2009/153554, Kudos Pharmaceuticals WO2010/136778, Genentech WO2010/014939]

J Am Chem Soc 2007, 129, 9566–9567. E Bergin, C T O’Connor, S B Robinson, E M McGarrigle, C P O’Mahony, D G Gilheany* — ‘Synthesis of P-Stereogenic Phosphorus Compounds. Asymmetric Oxidation of Phosphines under Appel Conditions.’ DOI: 10.1021/ja072925l [Winner of the 2008 Wesley Cocker award from the SCI for the best paper published in Ireland in 2007 of interest to the chemical industry]

Org Lett 2001, 3, 3435–3438. C P O’Mahony, E M McGarrigle, M F Renehan, K M Ryan, N J Kerrigan, C Bousquet, D G Gilheany* — ‘Asymmetric Alkene Epoxidation with Chromium Oxo Salen Complexes. A Systematic Study of Salen Ligand Substituents.’ DOI: 10.1021/ol010144y