Johno wins Poster Prize at CSCB symposium

johno1Congratulations to Johnathan Matlock who was awarded a prize for his poster at the recent CSCB symposium: “Recent Advances in Synthesis and Chemical Biology XIII“. The symposium, which was held in UCD, featured lectures from Profs Steve Buchwald (MIT), Guy Lloyd-Jones (Edinburgh), Dirk Trauner (Munich), Joost Reek (Amsterdam) and Rebecca Goss (St Andrews). ‘Johno’ presented his poster on the synthesis and applications of vinylsulfonium salts, focusing on the synthesis of heterocyclic compounds. This success follows on from publications in J Org Chem and Chem Eur J over the course of his PhD (jointly supervised by Eoghan and Prof Varinder Aggarwal (Bristol)). Johnathan will submit his PhD thesis very soon.


New paper in J Org Chem

Our latest paper has been published in the Journal of Organic Chemistry. The paper describes a way to make α-substituted vinylsulfonium salts and their application to the synthesis of pyrrolidines fused to either epoxides or cyclopropanes. These heterocycles should be useful building blocks for medicinal chemists. The paper arose from an ongoing collaboration with Prof Varinder Aggarwal at the University of Bristol, and researchers at GlaxoSmithKline. Congratulations to lead author Johnathan Matlock in particular, this is the second publication arising from his ongoing PhD research (supervised by Eoghan and Varinder).

JOC2014 AbstractThe paper is published online in the Journal of Organic Chemistry and can be accessed at the following link (with a subscription):

J Org Chem 2014 article ASAP. DOI: 10.1021/jo501885z

The research was funded by  EPSRC (Bristol Chemical Synthesis CDT), GSK, SFI and Marie-Curie COFUND.




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Paper published in Chemistry a European Journal

Our latest paper has just appeared online in Chemistry – A European Journal. The paper describes the use of vinylsulfonium salts to synthesise cyclopropane-fused heterocycles from readily available starting materials with excellent levels of diastereoselectivity. These interesting structures should be of particular interest to medicinal chemists. This paper arises from an ongoing collaboration with the Aggarwal group at the University of Bristol, UK. We thank EPSRC, GSK and SFI for funding.

ChemEurJ2013abstractThe paper can be read online (with a subscription):

Chem Eur J 2013, early view, doi: 10.1002/chem.201302081