Our latest paper has been published online in the RSC journal Org Biomol Chem. The paper describes a new way to make glycosyl chlorides using oxalyl chloride as chlorine source and just a catalytic amount of phosphine oxide. The reaction is very clean and so the product can be further reacted without purification in a subsequent organocatalytic glycosylation.
The paper comprises work by Imlirenla, Eoghan and our UCD colleague Kirill Nikitin. This is Ren’s second paper and first as lead author, so particular congratulations to her. The research was funded by Science Foundation Ireland (mostly under a CDA grant to Eoghan). The paper can be read online (currently with a valid subscription, open access will follow, reprints available, email Eoghan):
Org Biomol Chem 2019, advance article; I Pongener, K Nikitin and E M McGarrigle — Synthesis of Glycosyl Chlorides using Catalytic Appel Conditions. DOI: 10.1039/C9OB01544B
Congratulations to Martin who passed his PhD viva voce exam yesterday! This is culmination of 4 years of research for Martin. We had a party to celebrate of course. The examination was conducted by Prof. Marc Lecouvey (Univ. Paris 13) as the external examiner and Prof. Pat Guiry (UCD) as the internal examiner, with Prof Mike Casey (UCD) as chair. In the afternoon Prof. Lecouvey gave a seminar on his own research on “The Synthesis of Bisphosphorylated Compounds and their Applications in Biomedicine“. Martin’s PhD was sponsored by the Irish Research Council under a Government of Ireland Postgraduate Scholarship. Some of his PhD has been published in Synthesis last year and more publications will follow.
Our latest paper has been published online in the Journal of Organic Chemistry. The paper is Avene’s first paper, and details her identification of an impurity that was acting as a catalyst poison in thiourea-catalysed glycosylations. The impurity arose from the benzylation of an alcohol in DMF – a procedure that is carried out thousands of times per year all around the world. Despite this, the side-reaction that generates the impurity had not been noted in the scientific literature before. Well done to Avene on her excellent detective work, and congratulations also on her first crystal structure.
The paper can be read online at the link below:
J Org Chem 2016, Article ASAP; DOI: 10.1021/acs.joc.6b01914
If you don’t have a subscription and would like to read the article please email eoghan dot mcgarrigle at ucd dot ie to request a free article-on-request code.
The research was funded by the Irish Research Council and SFI.
You must be logged in to post a comment.