Ren’s new Paper in OBC

Our latest paper has been published online in the RSC journal Org Biomol Chem. The paper describes a new way to make glycosyl chlorides using oxalyl chloride as chlorine source and just a catalytic amount of phosphine oxide. The reaction is very clean and so the product can be further reacted without purification in a subsequent organocatalytic glycosylation.

The paper comprises work by Imlirenla, Eoghan and our UCD colleague Kirill Nikitin. This is Ren’s second paper and first as lead author, so particular congratulations to her. The research was funded by Science Foundation Ireland (mostly under a CDA grant to Eoghan). The paper can be read online (currently with a valid subscription, open access will follow, reprints available, email Eoghan):

Org Biomol Chem 2019, advance article; I Pongener, K Nikitin  and  E M McGarrigle — Synthesis of Glycosyl Chlorides using Catalytic Appel Conditions. DOI: 10.1039/C9OB01544B 

 

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ACIE article highlighted in SYNFACTS

Our recent paper in Angew. Chem. Int. Ed. has been highlighted in an article published in SYNFACTS. The article written by Prof Benjamin List and Ji Hye Kim appeared recently in SYNFACTS 2012, 8(10), 1145.

The article is also available online (to subscribers only) via http://www.thieme-connect.com/ejournals/toc/synfacts

Paper published online in Angew Chem

Our latest paper was published online today in Angew. Chem. Int. Ed. as an early view paper. The paper describes an organocatalytic method for forming disaccharides containing a 2-deoxy monosaccharide from galactals. Just 1 mol% of a thiourea catalyst is required for this highly efficient and stereoselective method. This work was carried out in collaboration with Dr Camen Galan and Ed Balmond at the University of Bristol, as well as Dr Diane Coe at GSK. Special congratulations to Ed (pictured). This is the first publication arising from his PhD research in Bristol. Ed is co-funded by GSK and the EPSRC-funded Bristol Chemical Synthesis Doctoral Training Centre.

The paper can be read (with a subscription) at the following links:

Angew. Chem. Int. Ed. 2012, early view; DOI: 10.1002/anie.201204505

Angew. Chem. 2012, early view; DOI: 10.1002/ange.201204505 [in German]

Poster presented at Madrid

We have just returned from the 26th International Carbohydrate Symposium in sunny Madrid. This was an excellent meeting and was a great opportunity to showcase some of our research into developing catalysts for carbohydrate chemistry to the glycoscience community. Ed Balmond presented a poster on the use of organocatalysts in glycosylation reactions which attracted lots of interest. The work is part of an ongoing collaboration with Carmen Galan (University of Bristol) and Diane Coe (GSK). In addition to lots of excellent science, there was time to experience some Spanish culture and enjoy some excellent Spanish food while we were in Madrid.