New Paper in Angewandte Chemie

Our latest publication was published online in Angew Chem Int Ed today. The paper describes how a cyclic disiloxane group controls the conformation of oxacarbenium ions, and leads to high selectivities in the synthesis of 2-deoxyglycosides from glucals and rhamnals. Some additional effects leading to higher selectivity were observed in the glucal series. This paper arose from a collaboration with Dr M Carmen Galan and Prof Roger Alder at the University of Bristol and Dr Diane Coe at GSK. Congratulations to Ed Balmond in particular – this is his second paper as first author in Angew Chem Int Ed.

The paper is published as an open access article in Angew Chem Int Ed and can be obtained at the following links:

Angew Chem Int Ed 2014, early view. DOI: 10.1002/anie.201403543

Angew Chem 2014, early view. DOI: 10.1002/ange.201403543

The research was funded by EPSRC (Bristol Chemical Synthesis CDT), GSK, SFI and Marie-Curie COFUND.

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Two Talks This Week

Eoghan presented the group’s research at two meetings this week. Firstly he gave a talk at the RSC Carbohydrate Group Spring Meeting, in Bath (UK). The highlight of the carbohydrate group meeting was the award of the Haworth Medal to Prof David Crich and his Award Lecture. Following this Eoghan spoke at the RSC Symposium on Stereochemistry in Dublin. This symposium was organised to coincide with the award of the RSC Stereochemistry Medal to Prof Peter O’Brien and the delivery of his Award Lecture. Pictured below are the speakers at the RSC Stereochemistry Symposium (Dr Chris Braddock, Dr Francesca Paradisi, Prof Declan Gilheany, Dr Matt Cook, Prof Peter O’Brien, Dr John Stephens, Prof Ray Jones (RSC Organic Division President), Eoghan and Prof Pat Guiry (symposium organizer)).

ACIE article highlighted in SYNFACTS

Our recent paper in Angew. Chem. Int. Ed. has been highlighted in an article published in SYNFACTS. The article written by Prof Benjamin List and Ji Hye Kim appeared recently in SYNFACTS 2012, 8(10), 1145.

The article is also available online (to subscribers only) via http://www.thieme-connect.com/ejournals/toc/synfacts

Paper published online in Angew Chem

Our latest paper was published online today in Angew. Chem. Int. Ed. as an early view paper. The paper describes an organocatalytic method for forming disaccharides containing a 2-deoxy monosaccharide from galactals. Just 1 mol% of a thiourea catalyst is required for this highly efficient and stereoselective method. This work was carried out in collaboration with Dr Camen Galan and Ed Balmond at the University of Bristol, as well as Dr Diane Coe at GSK. Special congratulations to Ed (pictured). This is the first publication arising from his PhD research in Bristol. Ed is co-funded by GSK and the EPSRC-funded Bristol Chemical Synthesis Doctoral Training Centre.

The paper can be read (with a subscription) at the following links:

Angew. Chem. Int. Ed. 2012, early view; DOI: 10.1002/anie.201204505

Angew. Chem. 2012, early view; DOI: 10.1002/ange.201204505 [in German]

Poster presented at Madrid

We have just returned from the 26th International Carbohydrate Symposium in sunny Madrid. This was an excellent meeting and was a great opportunity to showcase some of our research into developing catalysts for carbohydrate chemistry to the glycoscience community. Ed Balmond presented a poster on the use of organocatalysts in glycosylation reactions which attracted lots of interest. The work is part of an ongoing collaboration with Carmen Galan (University of Bristol) and Diane Coe (GSK). In addition to lots of excellent science, there was time to experience some Spanish culture and enjoy some excellent Spanish food while we were in Madrid.