Our latest publication has appeared online in Organic Letters today. The paper describes the use of substituted vinylsulfonium salts in the synthesis of 6- and 7-membered heterocycles with high regioselectivity and high diastereoselectivity. Saturated heterocycles such as morpholines and piperazines are present in approx 21% or all small molecule drugs approved by the FDA. We expect that this work will be of particular interest to medicinal chemists in drug discovery programs. Well done everybody.
The paper can be viewed online (with a subscription) at:
Org Lett, article ASAP; DOI: 10.1021/acs.orglett.5b02516
The research was funded by EPSRC (Bristol Chemical Synthesis CDT), GSK, SFI and the EU Marie-Curie COFUND.
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