Our latest paper has been published in the Journal of Organic Chemistry. The paper describes a way to make α-substituted vinylsulfonium salts and their application to the synthesis of pyrrolidines fused to either epoxides or cyclopropanes. These heterocycles should be useful building blocks for medicinal chemists. The paper arose from an ongoing collaboration with Prof Varinder Aggarwal at the University of Bristol, and researchers at GlaxoSmithKline. Congratulations to lead author Johnathan Matlock in particular, this is the second publication arising from his ongoing PhD research (supervised by Eoghan and Varinder).
The paper is published online in the Journal of Organic Chemistry and can be accessed at the following link (with a subscription):
J Org Chem 2014 article ASAP. DOI: 10.1021/jo501885z
The research was funded by EPSRC (Bristol Chemical Synthesis CDT), GSK, SFI and Marie-Curie COFUND.
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