Our latest paper has been published in the Journal of Organic Chemistry. The paper describes a way to make α-substituted vinylsulfonium salts and their application to the synthesis of pyrrolidines fused to either epoxides or cyclopropanes. These heterocycles should be useful building blocks for medicinal chemists. The paper arose from an ongoing collaboration with Prof Varinder Aggarwal at the University of Bristol, and researchers at GlaxoSmithKline. Congratulations to lead author Johnathan Matlock in particular, this is the second publication arising from his ongoing PhD research (supervised by Eoghan and Varinder).
The paper is published online in the Journal of Organic Chemistry and can be accessed at the following link (with a subscription):
J Org Chem 2014 article ASAP. DOI: 10.1021/jo501885z
The research was funded by EPSRC (Bristol Chemical Synthesis CDT), GSK, SFI and Marie-Curie COFUND.
Martin Ferry has been awarded a scholarship by the Irish Research Council. Competition for these awards is tough (>1000 applications were received and only 219 awards made). Director of the Irish Research Council, Eucharia Meehan congratulated the successful candidates, saying: “we are delighted to award this year’s postgraduate scholars with funding to continue their education and research projects, which are to an incredibly high standard.” The award enables Martin to begin his PhD in the group this Autumn. Martin developed the idea for his project while working as a final year project student last year. We are very happy to welcome Martin back to the group and congratulate him on his success.