Our latest paper was published online in Helvetica Chimica Acta in a special edition in honour of Prof Dieter Seebach’s 75th birthday. The paper describes the use of a new chiral vinylsulfonium salt for the synthesis of epoxide and aziridine-fused heterocycles. The method was applied to a synthesis of the core of the mitomycin class of antibiotics. This work was carried out in collaboration with Prof Varinder Aggarwal, Sven Fritz, Zulfiquar Ali and Dr Matt Unthank at the University of Bristol.
The paper can be read (with a subscription) at the following link:
Helv. Chim. Acta 2012, 95, 2384; DOI: 10.1002/hlca.201200455